When trying to Edit/Open Spreadsheet in Part Family, NX is unable because it keeps thinking without result.
After long time waiting an error comes up 'UGXML_dom_not_found_err'
Check your customer defaults.
Under Modeling-->Part Families-->All--> Keep All Part Family Add-ins in Spreadsheet (on)
After restarting NX, this will make your Part Family Spreadsheet editable.