In this example, the user has a Solid Edge sheet metal part and wants to create a Lofted Flange between two symmetrical profiles.
However, the resulting Lofted Flange is not symmetrical.
This is working as designed - Solid Edge does not process anything special for symmetrical sketches with regards to Lofted Flange.
The workaround is to edit the Lofted Flange and add vertex mapping to the side which is required to be symmetrical.
Now the Lofted Flange will appear as intended.