NX MCD connection error (Runtime error)

Mechatronics Concept Designer (MCD) Simulation failed with a Runtime error. The connection to CMVM seems to be the cause. 

Signal Connection was correct again after changing the application from MCD to (e.g.) Gateway and back to MCD. This workaround is not applicable when running MCD player.

Set following Mechatronic Concept Designer Parameters to solve this behavior:  

Mechatronics Concept Designer Preferences --> Sequence Editor --> Automatic Deactivate Operations = OFF 

Now the operations whose referencing runtime parameters have signals mapped with external signals, will not be disabled automatically anymore.