When working with multiple screens and the scaling option from the Windows "Scale and Layout" display settings, Solid Edge scales the interface from only the default screen.
Assuming that the basic screen is the laptop display (Full HD) and the additional screen is a 4K monitor, it is not possible to scale the Solid Edge interface. You can turn on a 4K monitor as the default screen, but in many cases it is undesirable.
SolutionWindows has an option that allows you to change the method of scaling Solid Edge: